Actin - binding proteins differentially regulate endothelial cell stiffness , ICAM - 1 function 1 and neutrophil
نویسندگان
چکیده
Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, 7 Academic Medical Center and Swammerdam Institute of Life Sciences, University of 8 Amsterdam, Amsterdam, The Netherlands; 9 Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud 10 University Nijmegen Medical Centre, Nijmegen, The Netherlands; 11 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, 12 The Netherlands; 13 Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, 14 Amsterdam, The Netherlands 15 16 * to whom correspondence should be addressed: 17 A. Schaefer (E-mail: [email protected]) or P.L. Hordijk (E-mail: [email protected]) 18 Department of Molecular Cell Biology 19 Sanquin Research and Landsteiner Laboratory, Academic Medical Center 20 and Swammerdam Institute of Life Sciences, 21 University of Amsterdam 22 Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands 23 24 25 26 Running Title: Stiffness controls ICAM-1 27
منابع مشابه
Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration.
Chronic vascular inflammation is driven by interactions between activated leukocytes and the endothelium. Leukocyte β2-integrins bind to endothelial intercellular adhesion molecule 1 (ICAM-1), which allows leukocyte spreading, crawling and transendothelial migration. Leukocytes scan the vascular endothelium for permissive sites to transmigrate, which suggests that there is apical membrane heter...
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